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1. Citation: Luoto, J., Maglione, M. A., Johnsen, B., Chang, C., Higgs, E. S., Perry, T., Shekelle, P. G. (2013). A comparison of frameworks evaluating evidence for global health interventions. PLOS Medicine, 1-6. doi: 10.1371/journal.pmed.1001469
Title: A Comparison of Frameworks Evaluating Evidence for Global health Interventions
Author(s): Luoto, J.
Maglione, M. A.
Johnsen, B.
Chang, C.
Higgs, E. S.
Perry, T.
Shekelle, P. G.
Year: 2013
Journal/Publication: PLoS Medicine


A major movement in global health and development in the past 10 years has been the enthusiastic adoption by many of randomized controlled trials (RCTs) from the field of medicine to represent the most rigorous method to evaluate a program's causal impact [1][4]. More recently, this movement has brought about a conceptual debate in global health and development about the proper role for RCTs in informing policy, with increasing efforts to “mind the gap” [5] between the evidence generated by RCTs (which focus on internal consistency) and the larger policy questions at the level of communities or populations (which require, among other things, generalizability) [4],[6][10]. The field of medicine that developed the RCT also developed the concept of “evidence-based” medicine that aims to improve health policy decision making by encouraging policymakers to base their policies on the best available evidence. Large international policy-making bodies appear set on applying a similar concept to global health and health systems research [4],[11]. In order to be evidence-based, decisions about global health interventions must consider the available evidence in terms of its quantity, quality, and relevance. Rather than use implicit judgment or other ad hoc methods, in evidence-based medicine it is now advocated and common practice to use a formal framework for considering the evidence as part of a systematic review, the advantages of which include increased transparency and better decision-making. Formal frameworks for evaluating evidence about community-level public health interventions have been proposed and advocated for similar reasons [12][17]. These frameworks differ in the degree to which they weight the importance of data from RCTs as compared to data from other study designs, the magnitude of potential benefits and harms, the role of context and implementation, and other factors. At present, there are no commonly accepted guidelines within global public health for how to evaluate evidence, and there is scant evidence to guide policymakers when selecting a framework to use for assessing a body of evidence about a global health intervention. We sought to assess how summary conclusions about the evidence for interventions or programs currently in use or proposed for wide adoption could be influenced by the choice of framework. Consistent results across frameworks would increase policymakers' confidence in using and applying evidence frameworks, and may thereby help to narrow the gap between the questions asked by global health researchers and policymakers. Inconsistent results would call for a re-examination of current frameworks in terms of the domains they assess and the ways in which they are applied.

Copyright © 2013 Luoto, J. et al. Abstract reprinted by AIR in compliance with the Creative Commons Attribution-Noncommercial-NoDerivs 3.0 Unported license at


Type of Item: Evaluation Instrument

Type of KT Strategy: Clinical Practice Guidelines

Target Group: Research Funders

Evidence Level: 2
Record Updated:2021-05-24