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||Creemers, H., Grupstra, H., Nollet, F., van den Berg, L. H., & Beelen, A. (2015). Prognostic factors for the course of functional status of patients with ALS: a systematic review. Journal of Neurology, 262(6), 1407-1423. doi:10.1007/s00415-014-7564-8
||Amyotrophic lateral sclerosis, Patient counseling, Disease progression, Prognosis
||Assesses factors predicting functional status in amyotrophic lateral sclerosis (ALS) as measured with the ALS Functional Rating Scale (ALSFRS). Finds that the prognostic value of age at onset, site of onset, time from symptom onset to diagnosis, and ALSFRS-Revised baseline score was low, while the prognostic value of initial rate of disease progression, age at diagnosis, forced vital capacity, frontotemporal dementia, body mass index, and comorbidity remains unclear. Concludes that current evidence on prognostic factors for functional decline in ALS is insufficient to allow the development of a prediction tool that can support clinical decisions.
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|Link to Full Text:||http://link.springer.com/article/10.1007%2Fs00415-014-7564-8|