||Smith, M. E., Haney, E., McDonagh, M., Pappas, M., Daeges, M., Wasson, N.,…Nelson, H. D. (2015). Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review for a National Institutes of Health Pathways to Prevention Workshop. Annals of Internal Medicine, 162(12), 841-850. doi:10.7326/M15-0114
||Aims to determine benefits and harms of treatments for adults with myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). Among 35 treatment trials 2 found that rintatolimod improved some measures of exercise performance compared with placebo (low strength of evidence). Trials of galantamine, hydrocortisone, IgG, valganciclovir, isoprinosine, fluoxetine, and various complementary medicines were inconclusive (insufficient evidence). Counseling therapies and graded exercise therapy compared with no treatment, relaxation, or support improved fatigue, function, global improvement, and work impairment in some trials; counseling therapies also improved quality of life (low to moderate strength of evidence). Harms were rarely reported across studies (insufficient evidence).