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1. Citation: Stitik, T. P., Issac, S. M., Modi, S., Nasir, S., & Kulinets, I. (2017). Effectiveness of 3 weekly injections compared with 5 weekly injection on intra-articular sodium hyaluronate on pain relief of knee osteoarthritis or 3 weekly injection of other hyaluronan products: A systematic review and meta-analysis. Archives of Physical Medicine and Rehabilitation, 98(5), 1042-1050. 
Keywords: Arthritis, drugs, intervention, joints, literature reviews, medical treatment, pain
Abstract: Study investigated whether the number of hyaluronic acid (HA) injections in a sodium hyaluronate (Hyalgan) course of therapy alters effectiveness in reducing knee osteoarthritis (OA) pain. Electronic databases, including PubMed and Embase, were searched from January 1980 until November 2015 for clinical studies that evaluated the effectiveness of a course of 3 or 5 weekly intra-articular injections of Hyalgan to treat knee OA pain. Clinical studies evaluating the effectiveness of a 3-week course of other Food and Drug Administration-approved HA treatments of knee OA pain were also included. Twenty-four studies were identified, comprising 2,168 study participants in 30 treated cohorts. Effect sizes for selected studies were determined by extracting knee OA pain scores before and after HA or control treatments. Meta-regressions were implemented to determine whether the number of weekly injections in a course of Hyalgan therapy modified outcomes. The pooled estimate for relief from baseline pain was −31.4 with a 3-week course of Hyalgan and −32.2 with a 5-week course of Hyalgan. Findings from the meta-analysis indicate relief of knee OA pain with a 3-week course of Hyalgan is similar to that with a 5-week course of Hyalgan. The pooled estimate for relief from baseline pain with a 3-week course of other HA products was −29.4, also indicating pain relief with a 3-week course of Hyalgan is similar to that with a 3-week course of other HA products. These findings demonstrate that comparable knee OA pain relief is achieved with a 3-week course of Hyalgan and the 2 control groups.
Full-Text Availability Options:https://www.archives-pmr.org/article/S0003-9993(17)30086-2/abstract
https://www.ncbi.nlm.nih.gov/pubmed/28232252
Record Updated:2018-11-15
 

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