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Registry of Systematic Reviews - Search Results

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1. Citation: Comper, P., Bisschop, S. M., Carnide, N., & Tricco, A. (2005). A systematic review of treatments for mild traumatic brain injury. Brain Injury, 19 (11), 863-880.
Keywords: mild traumatic brain injury, brain injury, mild, therapy, treatment, outcomes, interventions, rehabilitation
Abstract: Background: Traumatic brain injury is categorized into three levels of severity: mild, moderate, and severe. Most people with traumatic brain injury are diagnosed as mild. Mild traumatic brain injury (MTBI) symptoms vary and can result in serious challenges. There is a lack of data on interventions for MTBI. Clinicians have used interventions developed for moderate and severe TBI when treating people with MTBI.

Objectives: To conduct a systematic review on the effectiveness of interventions for people with MTBI.

Search strategy: The authors searched electronic databases: MEDLINE, EMBASE, CINAHL, HealthSTAR/Ovid Healthstar and PsychINFO.  Studies related to treatment of TBI and published between 1980 and 2003 were retrieved. Keywords used for the searches include the combinations of: brain injury, head injury, concussion, TBI, treatment, intervention, therapy, and rehabilitation. In addition 17 journals were hand searched for relevant articles. The reference lists of articles were also searched for relevant items.   

Selection criteria: Studies were included that involved: 1) participants between the ages 16-65; 2) treatment or intervention for MTBI; 3) treatment or intervention conducted within 5 years post-injury; 4) evidence of MTBI or TBI severity measures; and 5) a design other than case series or case study.

Data collection and analysis: Two researchers independently assessed the quality of the selected studies using a tool designed by the Public Health, Research and Education Development (PHRED) program.    

Main results: A total of 20 studies were included in the analysis. The authors reported findings on pharmacotherapy (8 studies), cognitive rehabilitation (3 studies), patient education (7 studies), and other interventions (2 studies). In addition, the methodological quality of the studies was reported. The findings suggest the effectiveness of patient education. However, no sufficient evidence was found for the pharmacotherapy and cognitive intervention.

Conclusion: Overall, the quality of the included studies was poor and many studies failed to report key components (e.g., MTBI research sample) needed for the evaluation of the intervention effectiveness. More scientifically rigorous studies on treatment for MTBI are needed.
Full-Text Availability Options:Available from NARIC.
Link to Full Text:,%20P.&rec=101024&article_source=Rehab&international=1&international_language=&international_location=
Record Updated:2017-02-17

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